Contents

Part I

Basic Aspects

1

Emerging Technologies: Gateway to Understand Molecular

Insight of Diseases, Newer Drugs, Their Design,

and Targeting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

3

R. C. Sobti, Mamtesh Kumari, Mandakini Singhla,

and Ranjana Bhandari

2

Polypharmacology: New Paradigms in Drug Development . . . . . . .

17

Tammanna R. Sahrawat and R. C. Sobti

3

Drug Repurposing in Biomedical Research: Benefits

and Challenges . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

27

Aashish Sharma and Jagdeep Kaur

4

Computational Methods for Drug Repurposing . . . . . . . . . . . . . . .

37

Sailu Yellaboina and Seyed E. Hasnain

5

Genomic Approaches for Drug Repositioning . . . . . . . . . . . . . . . . .

49

Isra Ahmad Farouk, Zheng Yao Low, Ashwini Puniyamurti,

Nur Zawanah Zabidi, Mohammad Khusni Ahmat Amin,

and Sunil Kumar Lal

6

Organ-on-a-Chip: Novel In Vitro Model for Drug Discovery . . . . .

73

Geeta Aggarwal, Gaurav Kaithwas, Manjari Singh,

and Ramesh K. Goyal

7

Precision Radiomolecular Oncology: Challenging the Classical

Statistical Evidence-Based Medicine . . . . . . . . . . . . . . . . . . . . . . . .

97

Baljinder Singh, Harneet Kaur, Ashwin Singh Parihar, Ankit Watts,

and Vikas Prasad

8

Drug Repositioning of the Phenylpiperazine Derivative

Naftopidil in Prostate Cancer Treatment . . . . . . . . . . . . . . . . . . . . .

111

Kenichiro Ishii, Yoshiki Sugimura, and Masatoshi Watanabe

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